Homology-mediated end-capping as a primary step of sister chromatid fusion in the breakage-fusion-bridge cycles
نویسندگان
چکیده
منابع مشابه
Homology-mediated end-capping as a primary step of sister chromatid fusion in the breakage-fusion-bridge cycles
Breakage-fusion-bridge (BFB) cycle is a series of chromosome breaks and duplications that could lead to the increased copy number of a genomic segment (gene amplification). A critical step of BFB cycles leading to gene amplification is a palindromic fusion of sister chromatids following the rupture of a dicentric chromosome during mitosis. It is currently unknown how sister chromatid fusion is ...
متن کاملChromatid and Chromosome Type Breakage-Fusion-Bridge Cycles
During the development of disomic additions of rye (Secale cereak L.) chromosomes to wheat (Triticum aestivum L.), two reverse tandem duplications on wheat chromosomes 3D and 4A were isolated. By virtue of their meiotic pairing, the reverse tandem duplications initiated the chromatid type of the breakagefusion-bridge (BFB) cycle. This BFB cycle continued through pollen mitoses and in the early ...
متن کاملChromatid and chromosome type breakage-fusion-bridge cycles in wheat (Triticum aestivum L.).
During the development of disomic additions of rye (Secale cereale L.) chromosomes to wheat (Triticum aestivum L.), two reverse tandem duplications on wheat chromosomes 3D and 4A were isolated. By virtue of their meiotic pairing, the reverse tandem duplications initiated the chromatid type of the breakage-fusion-bridge (BFB) cycle. This BFB cycle continued through pollen mitoses and in the earl...
متن کاملCombinatorics of the Breakage-Fusion-Bridge Mechanism
The breakage-fusion-bridge (BFB) mechanism was proposed over seven decades ago and is a source of genomic variability and gene amplification in cancer. Here we formally model and analyze the BFB mechanism, to our knowledge the first time this has been undertaken. We show that BFB can be modeled as successive inverted prefix duplications of a string. Using this model, we show that BFB can achiev...
متن کاملModelling Breakage-Fusion-Bridge Cycles as a Stochastic Paper Folding Process
Breakage-Fusion-Bridge cycles in cancer arise when a broken segment of DNA is duplicated and an end from each copy joined together. This structure then ‘unfolds’ into a new piece of palindromic DNA. This is one mechanism responsible for the localised amplicons observed in cancer genome data. The process has parallels with paper folding sequences that arise when a piece of paper is folded severa...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Nucleic Acids Research
سال: 2013
ISSN: 1362-4962,0305-1048
DOI: 10.1093/nar/gkt762